Nephrotoxicity, including acquired Fanconi’s syndrome, caused by adefovir dipivoxil - is there a safe dose?
نویسندگان
چکیده
منابع مشابه
There Is No Safe Dose of Prions
Understanding the circumstances under which exposure to transmissible spongiform encephalopathies (TSEs) leads to infection is important for managing risks to public health. Based upon ideas in toxicology and radiology, it is plausible that exposure to harmful agents, including TSEs, is completely safe if the dose is low enough. However, the existence of a threshold, below which infection proba...
متن کاملClinical features of hypophosphatemic osteomalacia induced by long-term low-dose adefovir dipivoxil
Objective To investigate the predictors of hypophosphatemic osteomalacia induced by adefovir dipivoxil (ADV) and to monitor for early detection. Patients and methods Hospitalized patients who were diagnosed with ADV-related hypo-phosphatemic osteomalacia were recruited and retrospectively analyzed in our hospital from January 2012 to December 2016. A telephone interview was conducted at 1, 3,...
متن کاملRelationship between nephrotoxicity and long-term adefovir dipivoxil therapy for chronic hepatitis B
BACKGROUND To assess the relationship between adefovir dipivoxil and renal function after anti-hepatitis B virus therapy and elucidate the risk factors involved. METHODS Based on the requirements of the Cochrane systematic review methodology, 21 observational articles on adefovir dipivoxil-associated renal dysfunction were obtained by searching various databases, between January 1, 1995 and J...
متن کاملPathologic Femoral Neck Fracture Due to Fanconi Syndrome Induced by Adefovir Dipivoxil Therapy for Hepatitis B
In Fanconi syndrome, hypophosphatemic osteomalacia is caused by proximal renal tubule dysfunction which leads to impaired reabsorption of amino acids, glucose, urate, and phosphate. We present a rare case of a 43-year-old Korean male who was found to have insufficiency stress fracture of the femoral neck secondary to osteomalacia due to Fanconi syndrome. He had been receiving low-dose adefovir ...
متن کاملHydrallazine in hypertension: is there a safe dose?
353 caesarean sections (incidence 25%). We do not think that the apparently high rate of surgical interference bears any relation to the use of intrathecal morphine, but it is too early yet to be sure. Our next eight patients (not reported here) all delivered spontaneously, thus reducing the incidence of both forceps delivery and caesarean section to 15 ". In 1979 the incidence of forceps deliv...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Pharmacy and Therapeutics
سال: 2011
ISSN: 0269-4727
DOI: 10.1111/j.1365-2710.2011.01278.x